Compositions and methods for pain management
AssigneeLoMed, Inc.
InventorDennis J. Bonner
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Abstract
Disclosed herein, in part, are pharmaceutical compositions comprising an opioid agonist such as codeine or a pharmaceutically acceptable salt thereof, hydroxyzine or a pharmaceutically acceptable salt thereof, a gabapentinoid, optionally a 5-HT3 antagonist and a pharmaceutically acceptable excipient. Methods of treating neuropathic and nociceptive pain comprising administering a disclosed pharmaceutical composition to a subject in need thereof is also provided herein
Claims22
A pharmaceutical composition comprising:
- codeine or a pharmaceutically acceptable salt thereof;
- hydroxyzine or a pharmaceutically acceptable salt thereof;
- a gabapentinoid;
- optionally a 5-HT3 antagonist;
- and
- a pharmaceutically acceptable excipient.
A pharmaceutical composition for treating neuropathic and deep tissue pain, comprising:
- (a) about 60 mg or about 120 mg codeine phosphate;
- (b) about 50 mg or about 100 mg hydroxyzine HCl;
- (c) about 4 mg ondansetron HCl;
- (d) about 300 mg or about 1200 mg gabapentin;
- (e) about 100 mg docusate sodium;
- and
- (f) a pharmaceutically acceptable excipient for controlled release.
A pharmaceutical composition comprising:
- about 60 mg or 120 mg codeine phosphate;
- about 20 mg to about 100 mg hydroxyzine HCl;
- optionally about 150 mg to about 600 mg gabapentin;
- and
- a pharmaceutically acceptable excipient.
An unit pharmaceutical composition comprising:
- about 30 mg or about 60 mg codeine phosphate;
- about 25 mg or about 50 mg hydroxyzine HCl;
- about 150 mg, about 300 mg, about 600 mg, or about 1200 mg gabapentin;
- about 2 mg ondansetron HCl;
- about 50 mg docusate Na;
- and
- a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.