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US 11,433,076 B2Granted
Preparation containing tetracyclic compound at high dose
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsTakashi Tomimatsu, Kensuke Okazaki, Yumi Ogawa, Takahiro Yamamura
Life of this patent
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Abstract
An improved solubility of a pharmaceutical composition or formulation containing a large amount of 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile or a salt thereof can be achieved by forming granules of the compound or salt thereof and allowing the granules to be present together with a disintegrating agent.
Claims16
A pharmaceutical formulation comprising granules containing a compound represented by formula (I) or a pharmaceutically acceptable salt thereof:
- wherein the granules have a mean particle diameter of 150 μm or more and wherein the granules have a bulk density of 0.5 g/ml or more and a tapping density of 0.6 g/ml or more.
Dependencies are inferred from the claim text.