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US 11,433,065 B2Granted
Certain chemical entities, compositions and methods
AssigneeIntellikine LLC
InventorsPingda Ren, Yi Liu, Troy Edward Wilson, Liansheng Li, Katrina Chan, Christian Rommel
Life of this patent
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Abstract
Chemical entities that modulate PI3 kinase activity, pharmaceutical compositions containing the chemical entities, and methods of using these chemical entities for treating diseases and conditions associated with P13 kinase activity are described herein.
Claims16
A compound of the Formula 406:
- or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt thereof, wherein:
- R′ is a moiety of Formula II:
- wherein Wc is aryl, heteroaryl, heterocycloalkyl, or cycloalkyl;
- q is an integer of 0, 1, 2, 3, or 4;
- R1 is hydrogen, alkyl, alkenyl, alkynyl, alkoxy, amido, alkoxycarbonyl, sulfonamido, halo, cyano, or nitro;
- each instance of R2 is independently alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, heteroarylalkyl, alkoxy, amino, halo, cyano, hydroxy or nitro;
- R3 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, alkoxy, amido, amino, alkoxycarbonyl, sulfonamido, halo, cyano, hydroxyl, or nitro;
- and
- R9 is hydrogen, C1-10 alkyl, cycloalkyl, or hetercycloalkyl.
6 more elements
A compound of the Formula 405:
- or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt thereof, wherein:
- R′ is a moiety of Formula II:
- wherein Wc is aryl, heteroaryl, heterocycloalkyl, or cycloalkyl;
- q is an integer of 0, 1, 2, 3, or 4;
- R1 is hydrogen, alkyl, alkenyl, alkynyl, alkoxy, amido, alkoxycarbonyl, sulfonamido, halo, cyano, or nitro;
- each instance of R2 is independently alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, heteroarylalkyl, alkoxy, amino, halo, cyano hydroxy or nitro;
- R3 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, alkoxy, amido, amino, alkoxycarbonyl, sulfonamido, halo, cyano, hydroxyl, or nitro;
- and
- R9 is hydrogen, C1-10alkyl, cycloalkyl, or hetercycloalkyl.
6 more elements
Dependencies are inferred from the claim text.