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US 11,433,057 B2Granted
Method for improving or enhancing cognition
AssigneeVanda Pharmaceuticals Inc.
InventorMihael H. Polymeropoulos
Life of this patent
Estimating the term…
Abstract
Disclosed herein are a method for improving cognition in an individual having findings consistent with a cognitive impairment, and a method of enhancing cognition in an individual. The methods include administering a therapeutically effective amount of (R)-3-(6-p-tolyl-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane or a metabolite or a pharmaceutically acceptable salt thereof to the individual.
Claims12
A method for improving cognition in a human individual having findings consistent with a cognitive impairment, the method comprising:
- administering a therapeutically effective amount of 13.5 to 16.5 mg/day of (R)-3-(6-p-tolyl-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane- or a pharmaceutically acceptable salt thereof to the human individual, and
- achieving a statistically significant improvement in a cognitive function measurement obtained in the human individual, after the human individual is administered the (R)-3-(6-p-tolyl-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane,
- wherein the cognitive impairment is Mild Cognitive Impairment amnestic mild cognitive impairment.
A method of enhancing cognition in a human individual, the method comprising:
- administering a therapeutically effective amount 13.5 to 16.5 mg/day of (R)-3-(6-p-tolyl-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane or a pharmaceutically acceptable salt thereof to the human individual, and
- achieving a statistically significant improvement in a cognitive function measurement obtained in the human individual, after the human individual is administered (R)-3-(6-p-tolyl-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane,
- wherein the human individual has findings consistent with a cognitive impairment.
Dependencies are inferred from the claim text.