5-LOX and COX-2 inhibition for treatment in connection with blood-brain barrier dysfunction
AssigneeUniversity of Kentucky Research Foundation
InventorsBjoern Bauer, Anika Maria Sophie Hartz, Brent Scot Sokola
Life of this patent
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Abstract
Methods of reducing blood brain barrier dysfunction involve inhibiting 5-LOX and COX-2.
Claims24
A method of reducing brain capillary leakage, comprising:
- identifying a subject having seizure, epilepsy, Alzheimer's disease and/or dementias, Parkinson's disease, brain cancer, multiple sclerosis, stroke, brain trauma, an infectious disease of the brain, and/or peripheral inflammation or inflammation of the central nervous system (CNS), and administering to the subject an effective amount of a composition to inhibit 5-LOX and COX-2 to reduce brain capillary leakage.
A method of reducing brain capillary leakage, for treating a subject for blood-brain barrier (BBB) dysfunction, comprising identifying the subject as having or being at risk of BBB dysfunction, and administering to the subject an effective amount of a composition to inhibit 5-LOX and COX-2.
A method of reducing brain capillary leakage, for treating a subject displaying epileptogenesis, comprising identifying the subject has displaying epileptogenesis, and administering to the subject the composition an effective amount of a composition to inhibit 5-LOX and COX-2.
Dependencies are inferred from the claim text.