Treatment of metabolic disorders in canine animals

A method of treatment of a metabolic disorder in a canine animal comprising administering to the canine animal a composition comprising one or more active agents, where the one or more active agents consist of one or more SGLT2 inhibitors or pharmaceutically acceptable forms thereof;

• wherein:
• the one or more SGLT-2 inhibitors or pharmaceutically acceptable forms thereof comprises 1-cyano-2-(4-cyclopropyl-benzyl)-4-(β-D-glucopyranos-1-yl)-benzene or a pharmaceutically acceptable form thereof represented by the following formula:
• the metabolic disorder is one or more selected from the group consisting of ketoacidosis, pre-diabetes, insulin dependent diabetes mellitus, insulin resistance diabetes, insulin resistance, obesity, hyperglycemia, hyperglycemia induced cataract formation, impaired glucose tolerance, hyperinsulinemia, dyslipidemia, dysadipokinemia, subclinical inflammation, systemic inflammation, low grade systemic inflammation, hepatic lipidosis, inflammation of the pancreas, metabolic disorder consequences comprising hypertension, renal dysfunction and/or musculoskeletal disorders, and Syndrome X (metabolic syndrome);
• and
• the one or more SGLT-2 inhibitors or pharmaceutically acceptable forms thereof is administered at a dose of no greater than 2.0 mg/kg bodyweight.