Methods and compositions for treating metabolic disorders
AssigneeJoslin Diabetes Center, Inc.
InventorsYu-Hua Tseng, Matthew Lynes
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Abstract
The invention includes methods and compositions for treating a metabolic disorder, such as metabolic syndrome, hyperlipidemia and associated disorders, such as obesity and diabetes. The invention includes a method of treating a human subject comprising administering 12,13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME) to the subject. Further provided is the use of 12,13-diHOME as a biomarker for identifying brown adipose tissue (BAT) activation in human subjects.
Claims8
A method of detecting a 12,13-diHOME level in a human subject to determine whether the human subject has brown adipose tissue activation, said method comprising
- a) obtaining a plasma sample from the human subject;
- b) detecting a 12,13-diHOME level in the plasma sample;
- and
- c) comparing the 12,13-diHOME level with a known baseline of plasma 12,13-diHOME level,
- such that it is determined whether the human subject has brown adipose tissue activation.
A method of determining whether a human subject has brown adipose tissue (BAT) activation, said method comprising determining the level of 12,13-diHOME in a plasma sample from the human subject, wherein a plasma 12,13-diHOME level of 0.2 pmol/mL or greater indicates BAT activation.
Dependencies are inferred from the claim text.