US 11,433,039 B2Granted

Composition and method for muscle repair and regeneration

AssigneeThomas Jefferson University

InventorsMasahiro Iwamoto, Maurizio Pacifici

Life of this patent

Estimating the term…

Loading patent…

Abstract

The invention provides methods for muscle repair or regeneration comprising administering therapeutically effective amounts of RAR agonists or stem cells that are pretreated with contact with a RAR agonist to a subject at a site of muscle damage. Additionally, the invention provides compositions comprising RAR agonist treated stem cells and methods of use of said cells for muscle repair or regeneration. In one embodiment, the stem cells are mesenchymal stem cells. In one embodiment, the RAR agonist is an RARγ agonist. In one embodiment, administration of the RAR agonist is begun during a period of increased endogenous retinoid signaling in the subject resulting from incurrence of the damaged muscle tissue.

Claims15

Dependent claims

A method of muscle repair or regeneration in a subject, comprising (i) providing pre-treated stem cells produced by contacting mesenchymal stem cells with an amount of a retinoic acid receptor gamma (RARγ) agonist effective to induce or stimulate myogenic differentiation;

and (ii) administering said pre-treated stem cells to a subject at a site of muscle injury to repair or regenerate muscle at the site, wherein the RARγ agonist is selected from the group consisting of CD-271 (6-(4-Methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid);
CD-394, CD-1530 (4-(6-Hydroxy-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl)benzoic acid);
CD-2247;
BMS-270394 (3-Fluoro-4-[(R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-acetylamino]-benzoic acid);
BMS-189961 (3-Fluoro-4-[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-acetylamino]-benzoic acid);
CH-55 (4-[(E)-3-(3,5-Di-tert-butyl-phenyl)-3-oxo-propenyl]-benzoic acid);
6-[3-(adamantan-1-yl)-4-(prop-2-ynyloxy)phenyl]naphthalene-2-carboxylic acid;
5-[(E)-3-oxo-3-(5,5,8,8-tetrahydronaphthalene-2-yl)propenyl]thiophene-2-carboxylic acid;
and enantiomers, derivatives, prodrugs, and pharmaceutically acceptable salts thereof.

6 more elements

Dependencies are inferred from the claim text.

Facts

Application: 16/379,178Filed 9 Apr 2019 · continuation
Priority: 1 Sep 2010
Published: US 2020/0069620 A15 Mar 2020
Granted: 6 Sep 2022
Term ends: Not estimatedThe source records don’t support an estimate.

Classification11 codes

A61K 31/203
Having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids: retinoic acids ; Salts thereof
A61P 19/08
Drugs for skeletal disorders: for bone diseases, e.g. rachitism, Paget's disease
A61K 31/185
Medicinal preparations containing organic active ingredients: acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic…
A61K 31/19
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids: carboxylic acids, e.g. valproic acid

Family

Application61/378,996Us provisional application · filed 1 Sep 2010
PCT/US2011/049905Parent of this continuation · filed 31 Aug 2011
Application15/674,357Parent of this continuation · filed 10 Aug 2017
US 9,789,074 B2Parent of this continuation · filed 17 Oct 2017
US 2020/0069620 A1Pre-grant publication · published 5 Mar 2020
US 10,292,954 B2Parent of this continuation
Application13/819,914Parent of this continuation
US 2014/0363402 A1Published application
US 2018/0000762 A1Published application
US 11,433,039 B2This patent

From the US filing history. Foreign family members aren’t listed.

Timeline

Citations

Open elsewhere

Building an agent or pulling many patents? Use the API or MCP server instead of scraping pages. Get an API key