Oral dosage form containing a fast release exterior coating
AssigneeGlaxoSmithKline Consumer Healthcare Holdings (US) LLC
InventorChristopher Joseph Pulford
Life of this patent
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Abstract
Aspects of the present invention are directed to an oral dosage form comprising a core containing one more active ingredients and a fast-release exterior coating. The fast release exterior coating includes a water soluble polymer; a saccharide or sugar alcohol, or a combination thereof, and a flavoring. The flavoring may be a warming sensate that is released in the oral cavity of the user after inserting the dosage form in his or her mouth.
Claims31
A coated oral dosage form that provides a sensorial experience in the oral cavity of the user, comprising:
- a core comprising between about 300 mg and about 400 mg acetaminophen, between about 5 mg and about 15 mg dextromethorphan, and between about 2.5 mg and about 7.5 mg phenylephrine;
- a fast-release exterior coating comprising:
- between about 2 mg and about 6 mg hydroxypropylmethylcellulose and polyethylene glycol, between about 3 mg and about 5 mg maltodextrin;
- and between about 0.5 mg and about 2.5 mg warming sensate;
- and
- an intermediate coating comprising between about 10 mg and about 20 mg hydroxypropylmethylcellulose and polyethylene glycol.
A coated oral dosage form that provides a sensorial experience in the oral cavity of the user, comprising:
- a core comprising between about 300 and about 400 mg acetaminophen, between about 10 mg and about 15 mg diphenhydramine, and between about 2.5 mg and about 7.5 mg phenylephrine;
- a fast-release exterior coating comprising between about 2 mg and about 6 mg hydroxypropylmethylcellulose;
- between about 3 mg and about 5 mg maltodextrin;
- and
- between about 0.5 mg and about 2.5 mg of a warming sensate;
- and
- an intermediate coating comprising between about 10 mg and about 20 mg hydroxypropylmethylcellulose.
A coated oral dosage form that provides a sensorial experience in the oral cavity of the user, comprising:
- a core comprising between about 300 mg and about 400 mg acetaminophen, between about 5 mg and about 15 mg dextromethorphan, and between about 2.5 mg and about 7.5 mg phenylephrine;
- a fast-release exterior coating comprising:
- between about 2 mg and about 6 mg hydroxypropylmethylcellulose, between about 3 mg and about 5 mg maltodextrin;
- and
- between about 0.5 mg and about 2.5 mg warming sensate;
- and.
- an intermediate coating comprising between about 10 mg and about 20 mg hydroxypropylmethylcellulose.
A coated oral dosage form that provides a sensorial experience in the oral cavity of the user, comprising:
- a core comprising between about 300 and about 400 mg acetaminophen, between about 10 mg and about 15 mg diphenhydramine, and between about 2.5 mg and about 7.5 mg phenylephrine;
- a fast-release exterior coating comprising between about 2 mg and about 6 mg hydroxypropylmethylcellulose and polyethylene glycol;
- between about 3 mg and about 5 mg maltodextrin;
- and between about 0.5 mg and about 2.5 mg of a warming sensate;
- and
- an intermediate coating comprising between about 10 mg and about 20 mg hydroxypropylmethylcellulose and polyethylene glycol.
Dependencies are inferred from the claim text.