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US 11,433,023 B2Granted
Albumin-PD-1 paclitaxel nanoparticle complex compositions and methods of making and using the same
AssigneeMayo Foundation for Medical Education and Research
InventorsSvetomir N. Markovic, Wendy K. Nevala
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Abstract
Described herein are compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic. Also described are lyophilized compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic.
Claims20
A lyophilized composition comprising nanoparticle complexes comprising
- albumin;
- antibodies, each having a programmed cell death protein 1 (PD-1)-binding portion;
- and paclitaxel;
- said nanoparticle complexes being lyophilized, and wherein upon reconstitution with an aqueous solution the nanoparticle complexes have binding specificity for PD-1 expressed by a cancer cell in vivo, wherein the antibodies are not pembrolizumab, wherein said complexes have an average size of less than 1 μm, and wherein the antibodies are associated with the albumin through non-covalent bonds.
1 more element
Dependencies are inferred from the claim text.