Left atrial appendage closure guidance in medical imaging

A method for left atrial appendage closure guidance with an ultrasound imager, the method comprising:

• transmitting ultrasound waves from the ultrasound imager to a patient;
• receiving echoed ultrasound waves with the ultrasound imager to obtain ultrasound data representing a heart volume of the patient;
• generating a three-dimensional anatomy model of the left atrial appendage of the patient from the ultrasound data representing the heart volume of the patient, the three-dimensional anatomy model of the left atrial appendage generated from the ultrasound data from landmark detection including detection of center of left atrial appendage, orifice boundary, tips of the left atrial appendage, left atrial appendage lobes, and bifurcations;
• displaying an image of an ostium of the left atrial appendage from the ultrasound data, a location of the ostium determined from the anatomy model generated from the ultrasound data, the location of the ostium defining a position of an image plane or slab for the ostium where the image of the ostium is limited to the image plane or slab;
• modeling placement of closure devices with respect to the anatomy model;
• simulating interactions of the closure devices with the anatomy model with a biomechanical model derived from the anatomy model;
• computing three-dimensional blood flows from the simulated interactions;
• selecting a first closure device of the closure devices as a function of the blood flow;
• and then
• outputting an image of anatomy of the patient, the image of the anatomy overlaid with a representation of the selected first closure device at the modeled placement for the selected first closure device.