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US 11,432,750 B2Granted
In vivo enzyme activity sensors and methods
AssigneeAbbott Diabetes Care Inc.
InventorsMark Eshoo, Benjamin Feldman, Tianmei Ouyang, Lam Tran
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Abstract
In vivo monitoring devices and systems for enzymes and/or analytes including devices having a reactant reservoir are provided.
Claims20
A continuous in vivo apparatus for determining the activity of an enzyme in vivo, comprising:
- a detection device comprising one or more working electrodes;
- a reaction area comprising the enzyme, the reaction area in fluid communication with the detection device and placed in contact with the one or more working electrodes;
- a storage reservoir containing a predetermined quantity of a reactant;
- at least one aperture passing through the one or more working electrodes, wherein the at least one aperture connects the storage reservoir to the reaction area proximate to a surface of the one or more working electrodes;
- wherein the storage reservoir passively provides the reactant to the reaction area only through egress from the at least one aperture;
- wherein the one or more working electrodes are configured to detect a product of a reaction of the reactant and the enzyme in the reaction area;
- and
- wherein at least a portion of the reaction area and the storage reservoir are implantable into a tissue.
5 more elements
A continuous in vivo apparatus for determining the activity of an enzyme in vivo, comprising:
- a storage reservoir containing a predetermined quantity of a reactant;
- a working electrode comprising at least one aperture;
- and
- a reaction layer arranged on the working electrode, wherein the reaction layer comprises an enzyme;
- wherein the reactant is passively released from the storage reservoir through the at least one aperture of the working electrode, wherein the working electrode is configured to detect a product of a reaction of the reactant with the enzyme in the reaction layer in order to produce a signal proportional to the activity of the enzyme, and
- wherein at least a portion of the apparatus is configured to be positioned beneath a skin surface.
3 more elements
A continuous in vivo apparatus for determining the activity of an enzyme in vivo, comprising:
- a working electrode comprising at least one aperture;
- a storage reservoir containing a predetermined quantity of a reactant, wherein the storage reservoir is arranged on a first side of the working electrode;
- and
- a reaction layer comprising an enzyme, wherein the reaction layer is arranged on an opposing, second side of the working electrode,
- wherein the reactant is configured to be passively released through the at least one aperture of the working electrode such that the reactant reacts with the enzyme in the reaction layer, and wherein the working electrode is configured to detect a product of a reaction of the reactant and the enzyme in the reaction layer.
2 more elements
Dependencies are inferred from the claim text.