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US 11,389,069 B2Granted
Hemodynamic reserve monitor and hemodialysis control
AssigneesFlashback Technologies, Inc., The Regents of the University of Colorado
InventorsGregory Zlatko Grudic, Steven L. Moulton, Isobel Jane Mulligan
Life of this patent
Estimating the term…
Abstract
Tools and techniques for estimating a probability that a patient is bleeding or has sustained intravascular volume loss (e.g., due to hemodialysis or dehydration) and/or to estimate a patient's current hemodynamic reserve index, track the patient's hemodynamic reserve index over time, and/or predict a patient's hemodynamic reserve index in the future. Tools and techniques for estimating and/or predicting a patient's dehydration state. Tools and techniques for controlling a hemodialysis machine based on the patient's estimated and/or predicted hemodynamic reserve index.
Claims42
A system, comprising:
- one or more sensors to obtain physiological data from a patient, wherein the physiological data is cardiovascular data of the patient;
- and
- a computer system in communication with the one or more sensors, the computer system comprising:
- one or more processors;
- and
- a non-transitory computer readable medium in communication with the one or more processors, the non-transitory computer readable medium having encoded thereon a set of instructions executable by the computer system to perform one or more operations, the set of instructions comprising:
- instructions for receiving the physiological data from the one or more sensors;
- instructions for analyzing the physiological data, wherein analyzing the physiological data further comprises:
- comparing the physiological data against a pre-existing model, the pre-existing model comprising a plurality of waveforms of reference data, each waveform of the plurality of waveforms corresponding to a respective hemodynamic reserve index value determined by the following formula:
- HDRI
-
- (
- t
- )
- =
- 1
- -
- BLV
-
- (
- t
- )
- BLV
- HDD
- where HDRI(t) is the hemodynamic reserve at time t, BLV(t) is an intravascular volume loss of the patient at time t, and BLVHDD is an intravascular volume loss of the patient at a point of hemodynamic decompensation, and
- wherein the physiological data includes waveform data of the patient, wherein waveform data of the patient includes one or more patient waveforms, wherein comparing the physiological data against the pre-existing model comprises comparing waveform data of the patient against the plurality of waveforms of reference data, and
- determining a similarity between a respective patient waveform of the one or more patient waveforms and each of one or more waveforms of the plurality of waveforms of reference data individually;
- instructions for estimating the hemodynamic reserve index value of the patient, based at least in part on the respective similarities of the respective patient waveform to each of the one or more waveforms of the plurality of waveforms of reference data individually;
- and
- instructions for taking one or more actions based on the estimated hemodynamic reserve index value of the patient.
27 more elements
A method, comprising:
- monitoring, with one or more sensors, physiological data of a patient, wherein the physiological data is cardiovascular data of the patient;
- analyzing, with a computer system, the physiological data, wherein analyzing the physiological data further comprises:
- comparing the physiological data against a pre-existing model, the pre-existing model comprising a plurality of waveforms of reference data, each waveform of the plurality of waveforms corresponding to a respective hemodynamic reserve index value determined by the following formula:
- HDRI
-
- (
- t
- )
- =
- 1
- -
- BLV
-
- (
- t
- )
- BLV
- HDD
- where HDRI(t) is the hemodynamic reserve at time t, BLV(t) is an intravascular volume loss of the patient at time t, and BLVHDD is an intravascular volume loss of the patient at a point of hemodynamic decompensation, and
- wherein the physiological data includes waveform data of the patient, wherein waveform data of the patient includes one or more patient waveforms, wherein comparing the physiological data against the pre-existing model comprises comparing waveform data of the patient against the plurality of waveforms of reference data, and
- determining a similarity between a respective patient waveform of the one or more patient waveforms and each of one or more waveforms of the plurality of waveforms of reference data individually;
- estimating, with the computer system, the hemodynamic reserve index value of the patient, based at least in part on respective similarities of the respective patient waveforms to each of the one or more waveforms of the plurality of waveforms of reference data individually;
- and
- taking, with the computer system, one or more actions based on the estimated hemodynamic reserve index value of the patient.
21 more elements
An apparatus, comprising:
- a non-transitory computer readable medium having encoded thereon a set of instructions executable by one or more computers to perform one or more operations, the set of instructions comprising:
- instructions for receiving physiological data from one or more sensors, wherein the physiological data is cardiovascular data of the patient;
- instructions for analyzing the physiological data, wherein analyzing the physiological data further comprises:
- comparing the physiological data against a pre-existing model, the pre-existing model comprising a plurality of waveforms of reference data, each waveform of the plurality of waveforms corresponding to a respective hemodynamic reserve index value determined by the following formula:
- HDRI
-
- (
- t
- )
- =
- 1
- -
- BLV
-
- (
- t
- )
- BLV
- HDD
- where HDRI(t) is the hemodynamic reserve at time t, BLV(t) is an intravascular volume loss of the patient at time t, and BLVHDD is an intravascular volume loss of the patient at a point of hemodynamic decompensation, and
- wherein the physiological data includes waveform data of the patient, wherein waveform data of the patient includes one or more patient waveforms, wherein comparing the physiological data against the pre-existing model comprises comparing waveform data of the patient against the plurality of waveforms of reference data, and
- determining a similarity between a respective patient waveform of the one or more patient waveforms and each of one or more waveforms of the plurality of waveforms of reference data individually;
- instructions for estimating, with the computer system, a hemodynamic reserve index value of the patient, based at least in part on respective similarities of the respective patient waveform to each of the one or more waveforms of the plurality of waveforms of reference data individually;
- and
- instructions for instructions for taking one or more actions based on the estimated hemodynamic reserve index value of the patient.
22 more elements
Dependencies are inferred from the claim text.