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US 11,382,571 B2Granted
Noninvasive predictive and/or estimative blood pressure monitoring
AssigneesFlashback Technologies, Inc., The Regents of the University of Colorado, a body corporate
InventorsIsobel Jane Mulligan, Gregory Zlatko Grudic, Steven L. Moulton
Life of this patent
Estimating the term…
Abstract
Tools and techniques for estimating and/or predicting a patient's current and/or future blood pressure. In some cases, the tools will analyze physiological data captured from the patient against a model of blood pressure values to estimate/predict the patient's blood pressure value. In particular cases, derived parameters, such as a patient's compensatory reserve index (“CRI”) can be analyzed against such models, while in other cases, data captured from sensors can be directly analyzed against such models.
Claims27
A system, comprising:
- one or more sensors to obtain physiological data from a patient, wherein the physiological data is cardiovascular data of the patient;
- and
- a computer system in communication with the one or more sensors, the computer system comprising:
- one or more processors;
- and
- a computer readable medium in communication with the one or more processors, the computer readable medium having encoded thereon a set of instructions executable by the computer system to perform one or more operations, the set of instructions comprising:
- instructions for receiving the physiological data from the one or more sensors;
- instructions for estimating a blood pressure value of the patient,
- wherein estimating the blood pressure value includes estimating a compensatory reserve index (“CRI”) value of the patient and estimating the blood pressure value from the estimated CRI value, wherein the CRI value of the patient is further used to estimate at least one of a dehydration state of the patient, a state of euvolemia of the patient, a state of hypervolemia of the patient, or a probability of bleeding of the patient,
- wherein estimating the CRI value of the patient includes comparing the physiological data to a model, the model comprising a plurality of waveforms of reference data, each waveform of the plurality of waveforms corresponding to a respective CRI value determined using the following formula:
- CRI
-
- (
- t
- )
- =
- 1
- -
- BLV
-
- (
- t
- )
- BLV
- HDD
- where CRI(t) is a compensatory reserve at time t, BLV(t) is an intravascular volume loss of the patient at time t, and BLVHDD is an intravascular volume loss at a point of hemodynamic decompensation of the patient,
- wherein the physiological data includes waveform data of the patient, wherein waveform data of the patient includes one or more patient waveforms,
- wherein comparing the physiological data against the model comprises comparing the waveform data of the patient against the plurality of waveforms of reference data, and
- determining a similarity between a respective patient waveform of the one or more patient waveforms and each of one or more waveforms of the plurality of waveforms of reference data individually, and
- wherein estimating the CRI value of the patient is based at least in part on respective similarities of the respective patient waveform to each of the one or more waveforms of the plurality of waveforms of reference data individually,
- wherein estimating the blood pressure value of the patient and the at least one of the dehydration state of the patient, the state of euvolemia of the patient, the state of hypervolemia of the patient, or the probability of bleeding of the patient includes comparing the CRI value of the patient to an empirical model, wherein the empirical model is separate from the model comprising the plurality of waveform data, wherein the blood pressure value and the at least one of the dehydration state of the patient, the state of euvolemia of the patient, the state of hypervolemia of the patient, or the probability of bleeding of the patient are related to the CRI value of the patient by the empirical model, wherein the empirical model is generated based on a test population, wherein the empirical model relates respective blood pressure values and at least one of the state of euvolemia, the state of hypovolemia, or the probability of bleeding to respective CRI values;
- and
- instructions for displaying, on a display device, an estimate of the blood pressure value of the patient.
30 more elements
A method, comprising:
- monitoring, with one or more sensors, physiological data of a patient, wherein the physiological data is cardiovascular data of the patient;
- estimating a blood pressure value of the patient,
- wherein estimating the blood pressure value includes estimating a compensatory reserve index (“CRI”) value of the patient and estimating the blood pressure value from the estimated CRI value, wherein the CRI value of the patient is further used to estimate at least one of a dehydration state of the patient, a state of euvolemia of the patient, a state of hypervolemia of the patient, or a probability of bleeding of the patient,
- wherein estimating the CRI value of the patient includes comparing the physiological data to a model, the model comprising a plurality of waveforms of reference data, each waveform of the plurality of waveforms corresponding to a respective CRI value determined using the following formula:
- CRI
-
- (
- t
- )
- =
- 1
- -
- BLV
-
- (
- t
- )
- BLV
- HDD
- where CRI(t) is a compensatory reserve at time t, BLV(t) is an intravascular volume loss of the patient at time t, and BLVHDD is an intravascular volume loss at a point of hemodynamic decompensation of the patient,
- wherein the physiological data includes waveform data of the patient, wherein waveform data of the patient includes one or more patient waveforms,
- wherein comparing the physiological data against the model comprises comparing the waveform data of the patient against the plurality of waveforms of reference data, and
- determining a similarity between a respective patient waveform of the one or more patient waveforms and each of one or more waveforms of the plurality of waveforms of reference data individually, and
- wherein estimating the CRI value of the patient is based at least in part on respective similarities of the respective patient waveform to each of the one or more waveforms of the plurality of waveforms of reference data individually,
- wherein estimating the blood pressure value of the patient and the at least one of the dehydration state of the patient, the state of euvolemia of the patient, the state of hypervolemia of the patient, or the probability of bleeding of the patient includes comparing the CRI value of the patient to an empirical model, wherein the empirical model is separate from the model comprising the plurality of waveform data, wherein the blood pressure value and the at least one of the dehydration state of the patient, the state of euvolemia of the patient, the state of hypervolemia of the patient, or the probability of bleeding of the patient are related to the CRI value of the patient by the empirical model, wherein the empirical model is generated based on a test population, wherein the empirical model relates respective blood pressure values and at least one of the state of euvolemia, the state of hypovolemia, or the probability of bleeding to respective CRI values;
- and
- displaying, on a display device, an estimate of the blood pressure value of the patient.
24 more elements
An apparatus, comprising:
- a non-transitory computer readable medium having encoded thereon a set of instructions executable by one or more computers to perform one or more operations, the set of instructions comprising:
- instructions for receiving physiological data of a patient from one or more sensors, wherein the physiological data is cardiovascular data of the patient;
- instructions for estimating a blood pressure value of the patient,
- wherein estimating the blood pressure value includes estimating a compensatory reserve index (“CRI”) value of the patient and estimating the blood pressure value from the estimated CRI value, wherein the CRI value of the patient is further used to estimate at least one of a dehydration state of the patient, a state of euvolemia of the patient, a state of hypervolemia of the patient, or a probability of bleeding of the patient,
- wherein estimating the CRI value of the patient includes comparing the physiological data to a model, the model comprising a plurality of waveforms of reference data, each waveform of the plurality of waveforms corresponding to a respective CRI value determined using the following formula:
- CRI
-
- (
- t
- )
- =
- 1
- -
- BLV
-
- (
- t
- )
- BLV
- HDD
- where CRI(t) is a compensatory reserve at time t, BLV(t) is an intravascular volume loss of the patient at time t, and BLVHDD is an intravascular volume loss at a point of hemodynamic decompensation of the patient,
- wherein the physiological data includes waveform data of the patient, wherein waveform data of the patient includes one or more patient waveforms,
- wherein comparing the physiological data against the model comprises comparing the waveform data of the patient against the plurality of waveforms of reference data, and
- determining a similarity between a respective patient waveform of the one or more patient waveforms and each of one or more waveforms of plurality of waveforms of reference data individually, and
- wherein estimating the CRI value of the patient is based at least in part on respective similarities of the respective patient waveform to each of the one or more waveforms of the plurality of waveforms of reference data individually,
- wherein estimating the blood pressure value of the patient and the at least one of the dehydration state of the patient, the state of euvolemia of the patient, the state of hypervolemia of the patient, or the probability of bleeding of the patient includes comparing the CRI value of the patient to an empirical model, wherein the empirical model is separate from the model comprising the plurality of waveform data, wherein the blood pressure value and the at least one of the dehydration state of the patient, the state of euvolemia of the patient, the state of hypervolemia of the patient, or the probability of bleeding of the patient are related to the CRI value of the patient by the empirical model, wherein the empirical model is generated based on a test population, wherein the empirical model relates respective blood pressure values and at least one of the state of euvolemia, the state of hypovolemia, or the probability of bleeding to respective CRI values;
- and
- instructions for displaying, on a display device, an estimate of the blood pressure value of the patient.
25 more elements
Dependencies are inferred from the claim text.