US 11,309,172 B2 · Reaction monitoring

Abstract

The invention generally relates to systems and methods for on-line reaction monitoring. In certain embodiments, the invention provides systems that include a reaction vessel having an outlet, a quantitation unit coupled to the outlet and configured to introduce internal standard and solvent into reaction solution flowed from the reaction vessel, one or more ion generating devices that receive flow from the quantitation unit, and a mass spectrometer. In certain embodiments, the invention provides systems for multiple reaction monitoring that include a plurality of reaction vessels, a plurality of ion generating devices, a plurality of channels, each channel coupling a reaction vessel to an ion generating device, an actuator coupled to the plurality of ion generating devices to thereby allow movement of the plurality of ion generating devices, and a mass spectrometer.

Claims10

Dependent claims

A reaction monitoring system, the system comprising:

a reaction vessel comprising an outlet;
a quantitation unit coupled to the outlet and configured to introduce internal standard and solvent into a reaction mixture flowed from the reaction vessel, wherein the quantitation unit comprises:
a first mixer in fluid communication with the outlet and an internal standard reservoir and operable to receive reaction mixture and internal standard respectively therefrom;
a second mixer in fluid communication with the first mixer and operable to receive mixed reaction mixture and internal standard therefrom;
a third mixer after the quantitation unit and in fluid communication with the second mixture, the third mixer comprising a first inlet that receives fluid flow from the second mixer, a second inlet that receives a spray solvent and an outlet;
one or more ion generating devices in fluid communication with the third mixer and operable to receive flow therefrom via one or more channels;
and
a mass spectrometer that receives ions from the one or more ion generating devices.

5 more elements

A system for quantifying multiple reactions, the system comprising:

a plurality of reaction vessels, each comprising an outlet;
a plurality of quantitation units each coupled to one of the outlets and configured to introduce internal standard and solvent into reaction solution flowed from one of the plurality of reaction vessels, wherein each of the plurality of quantitation units comprises a first mixer for receiving reaction solution, solvent, and internal standard and a second mixer for receiving the mixed reaction solution, solvent, and internal standard from the first mixer;
a plurality of third mixers, each coupled after each of the plurality of quantitation units to one of the outlets of the second mixers and in fluid communication with the second mixture of each of the plurality of quantitation units, each of the plurality of third mixers comprising a first inlet that receives fluid flow from the second mixer, a second inlet that receives a spray solvent and an outlet;
one or more ion generating devices for each of the plurality of quantitation units, the one or more ion generating devices each configured to receive flow from its associated third mixer of the plurality of third mixers via one or more channels connecting between each of the plurality of quantitation units and the one or more ion generating devices;
a mass spectrometer that receives ions from the one or more ion generating devices;
and
an actuator coupled to the one or more ion generating devices for each of the plurality of quantitation units to thereby allow movement of the one or more ion generating devices for each of the plurality of quantitation units relative to the mass spectrometer.

4 more elements

Dependencies are inferred from the claim text.

Reaction monitoring

Life of this patent

Reaction monitoring

Life of this patent

Abstract

Claims10