Back to results
US 11,309,088 B2Granted
Method, system, and computer readable medium for virtualization of a continuous glucose monitoring trace
AssigneeUniversity of Virginia Patent Foundation
InventorsStephen D. Patek, Marc D. Breton
Life of this patent
Estimating the term…
Abstract
A method and system use mathematical models and available patient information to virtualize a continuous glucose monitoring trace for a period of time. Such a method and system can generate the virtualized trace when episodic patient data is incomplete. Such a method and system can also rely on self-monitored blood glucose measurement information to improve the virtualized continuous glucose monitoring trace.
Claims12
A method for titrating insulin therapy for a patient, the method comprising:
- estimating, via an estimation module, a patient continuous glucose monitoring trace for a time period using a mathematical model, the mathematical model including a parameter that is representative of an estimated metabolic signal related to blood glucose excursions unexplained by the mathematical model;
- obtaining, via a communication module, patient episodic glucose data before the time period and over the time period;
- modifying, via an optimization module, the estimated patient continuous glucose monitoring trace for the time period to fit the obtained patient episodic glucose data over the time period using a cost function that penalizes:
- deviations of the estimated continuous glucose monitoring trace away from blood glucose samples of the episodic glucose data obtained before and/or during the time period;
- and
- a rate-of-change in the estimated metabolic signal that is greater than a pre-determined rate-of-change;
- and
- titrating, via a controller of an insulin delivery device, at least one of carbohydrate ratios, correction factors, correction thresholds and targets, or basal insulin doses based on the modified estimated patient continuous glucose monitoring trace.
5 more elements
A system for titrating insulin therapy for a patient, the system comprising:
- an estimation module configured to estimate a patient continuous glucose monitoring trace for a time period using a mathematical model, the mathematical model including a parameter that is representative of an estimated metabolic signal related to blood glucose excursions unexplained by the mathematical model;
- a communications module configured to received patient episodic glucose data before the time period and over the time period from a data source;
- an optimization module configured to modify the estimated patient continuous glucose monitoring trace for the time period to fit the obtained patient episodic glucose data over the time period using a cost function that penalizes:
- deviations of the estimated continuous glucose monitoring trace away from blood glucose samples of the episodic glucose data obtained before and/or during the time period;
- and
- a rate-of-change in the estimated metabolic signal that is greater than a pre-determined rate-of-change;
- and
- an insulin delivery device controller configured to titrate at least one of carbohydrate ratios, correction factors, correction thresholds and targets, or basal insulin doses based on the modified estimated patient continuous glucose monitoring trace.
5 more elements
Dependencies are inferred from the claim text.