A method of evaluating a vessel system of a patient to recommend an intervention for the patient, the method comprising:
- obtaining, at a processor, pressure measurements from a pressure-sensing instrument and a pressure-sensing guidewire positioned within a vessel of the patient while the pressure-sensing guidewire is moved longitudinally through the vessel from a first position to a second position, the pressure-sensing guidewire comprising a proximal portion, a distal portion, and a pressure sensor coupled to the distal portion;
- determining, based on the pressure measurements, a plurality of pressure ratios along a length of the vessel with a lesion, wherein the length of the vessel comprises a first plurality of locations defining a first segment and a second plurality of locations defining a second segment;
- obtaining, at the processor, external image data of the vessel;
- co-registering, with the processor, the plurality of pressure ratios with the external image data to produce first co-registered pressure ratios having a positional relationship with the first plurality of locations and second co-registered pressure ratios having the positional relationship with the second plurality of locations;
- determining, with the processor, first image-based physiologic measurements associated with the first segment and second image-based physiologic measurements associated with the second segment, from the external image data;
- calculating, with the processor, a first functional disease quantification score associated with the first segment and a second functional disease quantification score associated with the second segment, wherein the calculating comprises:
- determining a first image-based disease quantification score based on the first image-based physiologic measurements and a second image-based disease quantification score based on the second image-based physiologic measurements;
- and
- modifying the first image-based disease quantification score by a first factor to generate the first functional disease quantification score and the second image-based disease quantification score by a second factor to generate the second functional disease quantification score, wherein the first factor is determined based on the first co-registered pressure ratios such that the first functional disease quantification score is attributable to the positional relationship between the first co-registered pressure ratios and the first plurality of locations, and wherein the second factor is determined based on the second co-registered pressure ratios such that the second functional disease quantification score is attributable to the positional relationship between the second co-registered pressure ratios and the second plurality of locations;
- and
- outputting, to a display in communication with the processor, a graphical representation of the first functional disease quantification score, the second functional disease quantification score, the first image-based disease quantification score, and the second image-based disease quantification score.