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US 11,307,203 B2Granted
Using phage epitopes to profile the immune response
AssigneesThe Regents of the University of Michigan, Exact Sciences Development Company, LLC
InventorsArul M. Chinnaiyan, Xiaoju Wang, Alex Tsodikov, Jeanne Ohrnberger
Life of this patent
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Abstract
The present disclosure provides compositions and methods for using one or more polypeptide probes to profile an immune response. The polypeptide probe can be used to detect one or more antibodies from a sample. Furthermore, the present disclosure provides methods and compositions for characterizing a cancer based on the detection of one or more antibodies, such as autoantibodies.
Claims7
A kit, comprising:
- a plurality of polypeptide probes, wherein said polypeptide probes comprise all of:
- (i) amino acid sequence SEQ ID NO:
- 13 or an amino acid sequence encoded by nucleic acid sequence SEQ ID NO:
- 27,
- (ii) amino acid sequence SEQ ID NO:
- 132 or an amino acid sequence encoded by nucleic acid sequence SEQ ID NO:
- 162,
- (iii) amino acid sequence SEQ ID NO:
- 2 or an amino acid sequence encoded by nucleic acid sequence SEQ ID NO:
- 16,
- (iv) amino acid sequence SEQ ID NO:
- 141 or an amino acid sequence encoded by nucleic acid sequence SEQ ID NO:
- 171,
- (v) amino acid sequence SEQ ID NO:
- 129 or an amino acid sequence encoded by nucleic acid sequence SEQ ID NO:
- 159,
- (vi) amino acid sequence SEQ ID NO:
- 118 or an amino acid sequence encoded by nucleic acid sequence SEQ ID NO:
- 148,
- (vii) amino acid sequence SEQ ID NO:
- 122 or an amino acid sequence encoded by nucleic acid sequence SEQ ID NO:
- 152, and
- (viii) amino acid sequence SEQ ID NO:
- 130 or an amino acid sequence encoded by nucleic acid sequence SEQ ID NO:
- 160.
22 more elements
A kit, comprising:
- a plurality of polypeptide probes attached to a substrate, wherein said polypeptide probes comprise all of:
- (i) amino acid sequence SEQ ID NO:
- 13 or an amino acid sequence encoded by nucleic acid sequence SEQ ID NO:
- 27,
- (ii) amino acid sequence SEQ ID NO:
- 132 or an amino acid sequence encoded by nucleic acid sequence SEQ ID NO:
- 162,
- (iii) amino acid sequence SEQ ID NO:
- 2 or an amino acid sequence encoded by nucleic acid sequence SEQ ID NO:
- 16,
- (iv) amino acid sequence SEQ ID NO:
- 141 or an amino acid sequence encoded by nucleic acid sequence SEQ ID NO:
- 171,
- (v) amino acid sequence SEQ ID NO:
- 129 or an amino acid sequence encoded by nucleic acid sequence SEQ ID NO:
- 159,
- (vi) amino acid sequence SEQ ID NO:
- 118 or an amino acid sequence encoded by nucleic acid sequence SEQ ID NO:
- 148,
- (vii) amino acid sequence SEQ ID NO:
- 122 or an amino acid sequence encoded by nucleic acid sequence SEQ ID NO:
- 152, and
- (viii) amino acid sequence SEQ ID NO:
- 130 or an amino acid sequence encoded by nucleic acid sequence SEQ ID NO:
- 160.
22 more elements
Dependencies are inferred from the claim text.