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US 11,307,189 B2Granted
Method and probe apparatus for testing pharmaceutical products
AssigneeOxford University Innovation Limited
InventorsKamaljit Singh Chana, Saranjit Sihra, Pavinder Sagoo, Maxwell Adams, Vikram Sridhar
Life of this patent
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Abstract
A sensor element (4) is used to apply a heating pulse to a pharmaceutical product (6). Chemical or structural information about the pharmaceutical product is determined by measuring a response of the sensor element (4) during the heating pulse. The response is dependent on a heat transfer characteristic of the pharmaceutical product (6).
Claims14
A method of sensing a pharmaceutical product, comprising:
- using at least one sensor element to apply a first heating pulse and a second heating pulse to the pharmaceutical product;
- and determining chemical or structural information about the pharmaceutical product by measuring a first response of one of the at least one sensor element during the first heating pulse and a second response of one of the at least one sensor element during the second heating pulse, each response being dependent on a heat transfer characteristic of the pharmaceutical product, wherein:
- the information about the pharmaceutical product is at least partially obtained from a combination of the first measured response and the second measured response;
- and
- an average temperature of a region being sensed during obtaining of the first measured response is different from an average temperature of the region being sensed during obtaining of the second measured response.
2 more elements
A method of sensing, comprising:
- using at least one sensor element to apply a first heating pulse and a second heating pulse to a target material;
- and determining chemical or structural information about the target material by measuring a first response of one of the at least one sensor element during the first heating pulse and a second response of one of the at least one sensor element during the second heating pulse, each response being dependent on a heat transfer characteristic of the target material, wherein:
- the information about the target material is at least partially obtained from a combination of the first measured response and the second measured response;
- and
- an average temperature of a region being sensed during obtaining of the first measured response is different from an average temperature of the region being sensed during obtaining of the second measured response.
2 more elements
A method of sensing a pharmaceutical product, comprising:
- using a sensor element to apply a heating pulse to the pharmaceutical product;
- and
- determining chemical or structural information about the pharmaceutical product by measuring a response of the sensor element during the heating pulse, the response being dependent on a heat transfer characteristic of the pharmaceutical product, wherein:
- the sensor element comprises a resistive element and the heating pulse is applied by driving an electrical current through the resistive element;
- and
- wherein the resistive element is mounted on a substrate in such a way that at least 10% of the surface area of the resistive element is in contact with the substrate.
3 more elements
A method of sensing a pharmaceutical product, comprising:
- using a sensor element to apply a heating pulse to the pharmaceutical product;
- and
- determining chemical or structural information about the pharmaceutical product by measuring a response of the sensor element during the heating pulse, the response being dependent on a heat transfer characteristic of the pharmaceutical product,
- wherein the pharmaceutical product comprises plural layers of different chemical or structural composition, heat from the heating pulse propagates through the plural layers, and the measured response of the sensor element is analysed to identify one or more target time periods, each target time period being defined as a time period in which the response of the sensor element is determined predominantly by a different combination of one or more of the plural layers.
1 more element
Dependencies are inferred from the claim text.