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US 11,307,184 B2Granted
Sensor arrays with nucleophilic indicators
AssigneeiSense Corporation
InventorsSung Hyun Lim, Autumn Maruniak, Nuria Queralto Gratacos
Life of this patent
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Abstract
Sensors arrays that include indicators arranged in a pattern on a substrate. The indicators include nucleophilic indicators. In some examples, the sensor arrays with multiple nucleophilic indicators provide superior detection and identification of microorganisms, cancer biomarkers, formaldehyde, organophosphates, and aldehydes.
Claims18
A sensor array comprising:
- a substrate;
- a first nucleophilic indicator deposited on the substrate, the first nucleophilic indicator including a parosoaniline colorant;
- and
- a second nucleophilic indicator deposited on the substrate, the second nucleophilic indicator including an N-(rhodamine B)-deoxylactam-ethylenediamine colorant, wherein
- the first nucleophilic indicator and the second nucleophilic indicator are deposited at separate locations on the substrate in a predetermined pattern,
- each of the first nucleophilic indicator and the second nucleophilic indicator has a distinct spectral response to at least one distinct analyte, wherein a computer is configured to:
- capture a color change of the first nucleophilic indicator over a time period and a color change of the second nucleophilic indicator over the time period, in response to the at least one distinct analyte coming in contact with both the parosoaniline colorant and the N-(rhodamine B)-deoxylactam-ethylenediamine colorant, and
- compare the captured color change of the first nucleophilic indicator and the captured color change of the second nucleophilic indicator over the time period to a stored library of color response patterns to determine concentration of the at least one distinct analyte.
5 more elements
A method for detecting an analyte comprising:
- providing a sensor array comprising a first nucleophilic indicator and a second nucleophilic indicator deposited at separate locations on a substrate in a predetermined pattern, the first and second nucleophilic indicators having a distinct spectral response to at least one distinct analyte;
- exposing the sensor array to the at least one analyte;
- capturing, by a computer, a color change of the first nucleophilic indicator over a time period and a color change of the second nucleophilic indicator over the time period, in response to the at least one distinct analyte coming in contact with both a parosoaniline colorant in the first nucleophilic indicator and a N-(rhodamine B)-deoxylactam-ethylenediamine colorant in the second nucleophilic indicator;
- and
- comparing, by the computer, the captured color change of the first nucleophilic indicator and the captured color change of the second nucleophilic indicator over the time period to a stored library of color response patterns to determine a concentration of the at least one distinct analyte.
2 more elements
Dependencies are inferred from the claim text.