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US 11,307,178 B2Granted
Sampler for liquid chromatography
AssigneeDionex Softron GmbH
InventorThomas Wachinger
Life of this patent
Estimating the term…
Abstract
A sampler for liquid chromatography is described. The sampler includes an injection valve and a sample loop. The injection valve includes one waste port, two sample loop ports, and two high-pressure ports. The sample loop port includes a first loop part and a second loop part. The injection valve can be configured to have LOAD position and INJECT position. The injection valve can also be configured to have one or more additional positions such as a FULL PURGE position, a PUMP PURGE position, and a NEGATIVE PRESSURE position.
Claims17
A sampler for liquid chromatography, the sampler comprising:
- (A) an injection valve, the injection valve includes:
- (a) a stator, in which the stator comprises a first port, a second port, a third port, a fourth port, and a fifth port, wherein
- (i) the first port is configured to be connected to a pump;
- (ii) the second port configured to be connected to a chromatography column;
- (iii) the third port is connected to a sample loop;
- (iv) the fourth port is configured to discharge fluid at a low pressure to waste;
- and
- (v) a fifth port is connected to the sample loop;
- (b) a rotor, in which a face surface of the rotor is configured to be rotated against a face surface of the stator, the rotor comprises a first groove and a second groove, in which the first groove is configured to connect to two of the ports, and in which the second groove is configured to connect to a different two of the ports;
- (B) a sample delivery device connected to the sample loop;
- (C) the sample loop connected to the injection valve, the sample loop including:
- (a) a first sample loop part, in which a first end of the first sample loop part is connected to the fifth port and a second end of the first sample loop part is connected to the sample delivery device;
- and
- (b) a second sample loop part, in which a first end of the second sample loop part is connected to the third port and a second end of the second sample loop part is connected to the sample delivery device,
- in which the injection valve is configured to include a LOAD position, a PRESSURE EQUALIZATION position, and an INJECT position,
- (A1) in the LOAD position of the injection valve, the first groove connects the first port and the second port such that the first groove does not have a dead volume, and the second groove connects the third port and the fourth port;
- (A2) in the PRESSURE EQUALIZATION position of the injection valve, the first groove connects the first port and the second port such that the first groove does have the dead volume, and the second groove does not connect the third port and the fourth port;
- and
- (A3) in the INJECT position of the injection valve, the first groove connects the first port and the fifth port such that the first groove does not have the dead volume, and the second groove connects the second port and the third port.
16 more elements
Dependencies are inferred from the claim text.