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US 11,307,162 B2Granted
Highly sensitive biomarker biosensors based on organic electrochemical transistors
AssigneeThe Hong Kong Polytechnic University
InventorsFeng Yan, Ying Fu
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Abstract
The present technology for the detection and analysis of analytes within a sample is based on molecular biology methods, including western blotting, gel electrophoresis, mass spectrometry, enzyme-linked immunosorbent assays and RT-PCR, which are normally time-consuming and laborious. The present disclosure provides novel OECT based electrochemical biosensors that can enable the convenient and cost-effective determination of analytes within a sample with high sensitivity and selectivity.
Claims21
An electrochemical biosensor comprising a plurality of electrodes, comprising:
- a gate electrode comprising a first agent capable of specifically binding to an analyte in a sample;
- a source electrode;
- a drain electrode;
- a channel comprising an organic semiconductor between the source electrode and the drain electrode;
- a plurality of gold nanoparticles comprising an electrochemically active enzyme and a second agent capable of specifically binding to the analyte in the sample;
- and
- a substrate for the electrochemically active enzyme,
- wherein the gate electrode and the channel are separated by an electrolyte, and wherein the electrolyte contacts the gate electrode and the channel.
5 more elements
Dependencies are inferred from the claim text.