Method of producing isoprenoids and proteins, genes, and transformants for the same

A transformant comprising an isolated gene inserted thereinto, and expressing the isolated gene, provided that the transformant is transformed isoprenoid-producing filamentous fungi, wherein the isolated gene comprises any one of nucleotide sequences of (1) to (4) below that encode an amino acid sequence of an enzyme having an activity of catalyzing monooxygenation of ilicicolin A epoxide:

• (1) a nucleotide sequence set forth in SEQ ID NO:
• 8;
• (2) a nucleotide sequence having 90% or more sequence identity to the nucleotide sequence set forth in SEQ ID NO:
• 8;
• (3) a nucleotide sequence encoding an amino acid sequence having 90% or more sequence identity to the amino acid sequence set forth in SEQ ID NO:
• 18;
• and
• (4) a nucleotide sequence encoding an amino acid sequence having 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 amino acids deleted, substituted, and/or added in the amino acid sequence set forth in SEQ ID NO:
• 18, provided that the amino acids are those per unit when 100 amino acids in the amino acid sequence are considered as one unit.