Peptide, complex of peptide and siRNA, and methods of use thereof
AssigneesPositec Power Tools (Suzhou) Co., Ltd., Pu Chen
InventorsPu Chen, Dafeng Chu, Baoling Chen, Wen Xu, Ran Pan
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Abstract
A series of peptides and a peptide-siRNA complex are disclosed, wherein the peptide based complex effectively enhances delivery of siRNA molecules into the cells and release of siRNA in the cell, and improves siRNA mediated gene silencing efficiency of cellular targets. Pharmaceutical compositions that include the complex, as well as a use of the complex in the gene therapy field, are also disclosed.
Claims20
A peptide having the sequence CH3(CH2)16CONH—B—CONH2, wherein B is SEQ ID NO:4 or 5.
A complex comprising:
- a cargo molecule;
- and
- a peptide having the sequence CH3(CH2)16CONH—B—CONH2, wherein B is SEQ ID NO:4 or 5.
A pharmaceutical composition containing a complex comprising:
- a cargo molecule;
- and
- a peptide having the sequence CH3(CH2)16CONH—B—CONH2, wherein B is SEQ ID NO:4 or 5.
A kit used to deliver drugs to a patient, wherein the kit comprises:
- a pharmaceutical composition comprising a complex comprising:
- a cargo molecule;
- and
- a peptide having the sequence CH3(CH2)16CONH—B—CONH2, wherein B is SEQ ID NO:4 or 5;
- one or more electrolytes;
- one or more buffers;
- a delivery device;
- and
- a container adapted to mix one or more other agents together.
Dependencies are inferred from the claim text.