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US 11,306,304 B2Granted
Mutations in iron-sulfur cluster proteins that improve xylose utilization
AssigneeLallemand Hungary Liquidity Management LLC
InventorsAllan Froehlich, Brooks Henningsen, Sean Covalla, Rintze M. Zelle
Life of this patent
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Abstract
There is provided an engineered host cells comprising (a) one or more mutations in one or more endogenous genes encoding a protein associated with iron metabolism; and (b) at least one gene encoding a polypeptide having xylose isomerase activity, and methods of their use thereof.
Claims16
A recombinant yeast cell comprising (a) at least one heterologous gene encoding a protein associated with iron metabolism and/or one or more mutations in one or more endogenous gene encoding a protein associated with iron metabolism;
- and (b) at least one heterologous gene encoding a polypeptide having xylose isomerase activity;
- wherein the gene encoding a protein associated with iron metabolism is YFH1.
Dependencies are inferred from the claim text.