Virus-like particles which can be used in the treatment of autoimmune diseases
AssigneesSorbonne Universite, Inserm (Institut National De La Sante Et De La Recherche Medicale), Assistance Publique-Hopitaux de Paris
InventorsBertrand Bellier, David Klatzmann
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Abstract
The invention relates to a virus-like particle comprising an autoantigen and an immunoregulatory molecule exposed on its surface. The invention also relates to the use of said particle in the treatment of an autoimmune disease.
Claims13
A virus-like particle comprising an antigen and an immunoregulatory molecule exposed on the surface of the particle, wherein the antigen is an autoantigen, the immunoregulatory molecule is linked to the transmembrane glycoprotein domain of vesicular stomatitis virus (VSV-G) or to the glycophosphatidylinositol (GPI) anchoring domain of the CD59 glycoprotein, and the virus-like particle is a synthetic retroviral particle.
Dependencies are inferred from the claim text.