Anti-podoplanin antibody
AssigneesTohoku University, Zenogen Pharma Co., Ltd.
InventorsYukinari Kato, Mika Kato, Shinji Yamada, Satoshi Ogasawara, Takuro Nakamura
Life of this patent
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Abstract
The present invention provides a cancer cell-specific anti-podoplanin antibody or an antigen-binding fragment thereof having an epitope in a Thr85-containing region of an amino acid sequence of human podoplanin represented by SEQ ID NO: 1, the Thr85 having a sialylated O-glycan added thereto.
Claims18
A cancer cell-specific anti-podoplanin antibody or antigen-binding fragment thereof, comprising the following six CDR amino acid sequences:
- heavy chain CDR1:
- (SEQ ID NO:
- 2)
- GFTFSNAAMY
- heavy chain CDR2:
- (SEQ ID NO:
- 3)
- RIRSKPNNYATYYTDSVKG
- heavy chain CDR3:
- (SEQ ID NO:
- 4)
- TVGGNNYAAAY
- light chain CDR1:
- (SEQ ID NO:
- 5)
- RSSQSLVHSNGNTYLE
- light chain CDR2:
- (SEQ ID NO:
- 6)
- KVSNRFS
- light chain CDR3:
- (SEQ ID NO:
- 7)
- FQVTHDPFT.
A cancer cell-specific anti-podoplanin antibody or antigen-binding fragment thereof, comprising the following six CDR amino acid sequences:
- heavy chain CDR1:
- (SEQ ID NO:
- 2)
- GFTFSNAAMY,
- heavy chain CDR2:
- (SEQ ID NO:
- 3)
- RIRSKPNNYATYYTDSVKG,
- heavy chain CDR3:
- (SEQ ID NO:
- 4)
- TVGGNNYAAAY,
- light chain CDR1:
- (SEQ ID NO:
- 5)
- RSSQSLVHSNGNTYLE,
- light chain CDR2:
- (SEQ ID NO:
- 6)
- KVSNRFS,
- and
- light chain CDR3:
- (SEQ ID NO:
- 7)
- FQVTHDPFT;
- wherein the heavy chain has an amino acid sequence that:
- is represented by SEQ ID NO:
- 8 or 10;
- is obtained by addition, substitution, or deletion of one to several amino acids from the amino acid sequence represented by SEQ ID NO:
- 8 or 10;
- has 80% or more identity to the amino acid sequence represented by SEQ ID NO:
- 8 or 10;
- and
- wherein the light chain has an amino acid sequence that:
- is represented by SEQ ID NO:
- 9 or 11;
- is obtained by addition, substitution or deletion of one to several amino acids from the amino acid sequence represented by SEQ ID NO:
- 9 or 11, or
- has 80% or more identity to the amino acid sequence represented by SEQ ID NO:
- 9 or 11.
Dependencies are inferred from the claim text.