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US 11,306,142 B2Granted
Bispecific antibodies to ROR1 and CD3
AssigneeUCL Business PLC
InventorsAmit Nathwani, Satyen Gohil, Marco Della Peruta
Life of this patent
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Abstract
There is described bispecific antibodies which selectively bind to Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1) and the CD3 subunit of the T-Cell Receptor (TCR), their production and their use. Also described is the use of the bispecific antibodies in the treatment of cancer.
Claims16
A bispecific antibody comprising a first antigen binding domain which selectively binds to Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1);
- and
- a second antigen binding domain which selectively binds to the CD3 subunit of the T-Cell Receptor (TCR);
- wherein the first antigen binding domain comprises a light chain variable domain and a heavy chain variable domain, wherein the light chain variable domain comprises a light chain complementarity determining region (LCDR)1, an LCDR2 and an LCDR3, wherein LCDR1 comprises the amino acid sequence set forth in SEQ ID NO:
- 16;
- LCDR2 comprises the amino acid sequence set forth in SEQ ID NO:
- 18;
- and LCDR3 comprises the amino acid sequence set forth in SEQ ID NO:
- 20;
- and wherein the heavy chain variable domain comprises a heavy chain complementarity determining region (HCDR)1, an HCDR2 and an HCDR3, wherein HCDR1 comprises the amino acid sequence set forth in SEQ ID NO:
- 23;
- HCDR2 comprises the amino acid sequence set forth in SEQ ID NO:
- 25;
- and HCDR3 comprises the amino acid sequence set forth in SEQ ID NO:
- 57;
- and
- wherein the second antigen binding domain comprises a light chain variable domain and a heavy chain variable domain, wherein the light chain variable domain comprises a LCDR1, an LCDR2 and an LCDR3 as shown in any one of SEQ ID NOs:
- 63-68;
- and wherein the heavy chain variable domain comprises a HCDR1, an HCDR2 and an HCDR3 as shown in any one of SEQ ID NOs:
- 69-74.
16 more elements
A bispecific antibody comprising a first antigen binding domain which selectively binds to Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1);
- and
- a second antigen binding domain which selectively binds to the CD3 subunit of the T-Cell Receptor (TCR), wherein for the first antigen binding domain:
- (a) the light chain variable domain comprises the amino acid sequence as set forth as SEQ ID NO:
- 3 and the heavy chain variable domain comprises the amino acid sequence as set forth as SEQ ID NO:
- 9;
- (b) the light chain variable domain comprises the amino acid sequence as set forth as SEQ ID NO:
- 4 and the heavy chain variable domain comprises the amino acid sequence as set forth as SEQ ID NO:
- 10;
- (c) the light chain variable domain comprises the amino acid sequence as set forth as SEQ ID NO:
- 5 and the heavy chain variable domain comprises the amino acid sequence as set forth as SEQ ID NO:
- 11;
- (d) the light chain variable domain comprises the amino acid sequence as set forth as SEQ ID NO:
- 6 and the heavy chain variable domain comprises the amino acid sequence as set forth as SEQ ID NO:
- 12;
- (e) the light chain variable domain comprises the amino acid sequence as set forth as SEQ ID NO:
- 7 and the heavy chain variable domain comprises the amino acid sequence as set forth as SEQ ID NO:
- 13;
- or
- the light chain variable domain comprises the amino acid sequence as set forth as SEQ ID NO:
- 8 and the heavy chain variable domain comprises the amino acid sequence as set forth as SEQ ID NO:
- 14;
- and,
- wherein for the second antigen binding domain:
- (a) the light chain variable domain comprises the amino acid sequence as set forth as SEQ ID NO:
- 63 and the heavy chain variable domain comprises the amino acid sequence as set forth as SEQ ID NO:
- 69;
- (b) the light chain variable domain comprises the amino acid sequence as set forth as SEQ ID NO:
- 64 and the heavy chain variable domain comprises the amino acid sequence as set forth as SEQ ID NO:
- 70;
- (c) the light chain variable domain comprises the amino acid sequence as set forth as SEQ ID NO:
- 65 and the heavy chain variable domain comprises the amino acid sequence as set forth as SEQ ID NO:
- 71;
- (d) the light chain variable domain comprises the amino acid sequence as set forth as SEQ ID NO:
- 66 and the heavy chain variable domain comprises the amino acid sequence as set forth as SEQ ID NO:
- 72;
- (e) the light chain variable domain comprises the amino acid sequence as set forth as SEQ ID NO:
- 67 and the heavy chain variable domain comprises the amino acid sequence as set forth as SEQ ID NO:
- 73;
- or
- (f) the light chain variable domain comprises the amino acid sequence as set forth as SEQ ID NO:
- 68 and the heavy chain variable domain comprises the amino acid sequence as set forth as SEQ ID NO:
- 74.
39 more elements
Dependencies are inferred from the claim text.