Antibody against human DLK1 and use thereof

An antibody or an antigen-binding fragment thereof specifically binding to delta-like 1 homolog (DLK1), comprising the following heavy-chain variable region and light-chain variable region:

• a heavy-chain variable region comprising heavy-chain CDR1 of SEQ ID. NO:
• 16, heavy-chain CDR2 of SEQ ID. NO:
• 18, heavy-chain CDR3 of SEQ ID. NO:
• 20, a light-chain variable region comprising light-chain CDR1 of SEQ ID. NO:
• 23, light-chain CDR2 of SEQ ID. NO:
• 25, light-chain CDR3 of SEQ ID. NO:
• 27,
• a heavy-chain variable region comprising heavy-chain CDR1 of SEQ ID. NO:
• 72, heavy-chain CDR2 of SEQ ID. NO:
• 74, heavy-chain CDR3 of SEQ ID. NO:
• 76, a light-chain variable region comprising light-chain CDR1 of SEQ ID. NO:
• 79, light-chain CDR2 of SEQ ID. NO:
• 81, light-chain CDR3 of SEQ ID. NO:
• 83,
• a heavy-chain variable region comprising heavy-chain CDR1 of SEQ ID. NO:
• 16, heavy-chain CDR2 of SEQ ID. NO:
• 18, heavy-chain CDR3 of SEQ ID. NO:
• 20, a light-chain variable region comprising light-chain CDR1 of SEQ ID. NO:
• 115, light-chain CDR2 of SEQ ID. NO:
• 95, light-chain CDR3 of SEQ ID. NO:
• 116, or
• a heavy-chain variable region comprising heavy-chain CDR1 of SEQ ID. NO:
• 16, heavy-chain CDR2 of SEQ ID. NO:
• 18, heavy-chain CDR3 of SEQ ID. NO:
• 20, a light-chain variable region comprising light-chain CDR1 of SEQ ID. NO:
• 121, light-chain CDR2 of SEQ ID. NO:
• 39, light-chain CDR3 of SEQ ID. NO:
• 124.