Antibody molecules and uses thereof

A method of treatment of a Candida infection comprising administering an anti-Candida antibody molecule to an individual in need thereof, wherein the antibody molecule is a whole antibody comprising a VH domain comprising:

• (i) a HCDR1 having the amino acid sequence of SEQ ID NO:
• 39;
• (ii) a HCDR2 having the amino acid sequence of SEQ ID NO:
• 41;
• and
• (iii) a HCDR3 having the amino acid sequence of SEQ ID NO:
• 43;
• and a VL domain comprising:
• (i) a LCDR1 having the amino acid sequence of SEQ ID NO:
• 46;
• (ii) a LCDR2 having the amino acid sequence of SEQ ID NO:
• 48;
• and
• (iii) a LCDR3 having the amino acid sequence of SEQ ID NO:
• 50.

A method for detecting the presence or absence of a fungus which is a Candida spp, the method comprising

• (i) contacting a sample suspected of containing the fungus with an anti-Candida antibody molecule, and
• (ii) determining whether the anti-Candida antibody molecule binds to the sample, binding of the antibody molecule to the sample indicates the presence of the fungus, and wherein the anti-Candida antibody molecule comprises a VH domain comprising:
• (i) a HCDR1 having the amino acid sequence of SEQ ID NO:
• 39;
• (ii) a HCDR2 having the amino acid sequence of SEQ ID NO:
• 41;
• and
• (iii) a HCDR3 having the amino acid sequence of SEQ ID NO:
• 43;
• and a VL domain comprising
• (i) a LCDR1 having the amino acid sequence of SEQ ID NO:
• 46;
• (ii) a LCDR2 having the amino acid sequence of SEQ ID NO:
• 48;
• and
• (iii) a LCDR3 having the amino acid sequence of SEQ ID NO:
• 50.

A lateral flow device (LFD) for detecting the presence of an analyte which is a fungal pathogen in a sample fluid,

• wherein said LFD comprises:
• (i) a housing, and
• ii) at least one flow path leading from a sample well to a viewing window, wherein said flow path comprises one or more carriers along which the sample fluid is capable of flowing by capillary action, and wherein the one or more carriers comprise an analyte-detecting means;
• wherein the presence of analyte produces a line in the viewing window which indicates the presence of the fungal pathogen,
• wherein the fungal pathogen is a Candida spp. and the at least one analyte-detecting means is an anti-Candida antibody molecule comprising a VH domain comprising:
• (i) a HCDR1 having the amino acid sequence of SEQ ID NO:
• 39;
• (ii) a HCDR2 having the amino acid sequence of SEQ ID NO:
• 41;
• and
• (iii) a HCDR3 having the amino acid sequence of SEQ ID NO:
• 43;
• and a VL domain comprising:
• (i) a LCDR1 having the amino acid sequence of SEQ ID NO:
• 46;
• (ii) a LCDR2 having the amino acid sequence of SEQ ID NO:
• 48;
• and
• (iii) a LCDR3 having the amino acid sequence of SEQ ID NO:
• 50.

A method comprising contacting a Candida cell with an anti-Candida antibody molecule, wherein the anti-Candida antibody molecule comprises a VH domain comprising:

• (i) a HCDR1 having the amino acid sequence of SEQ ID NO:
• 39;
• (ii) a HCDR2 having the amino acid sequence of SEQ ID NO:
• 41;
• and
• (iii) a HCDR3 having the amino acid sequence of SEQ ID NO:
• 43;
• and a VL domain comprising:
• (i) a LCDR1 having the amino acid sequence of SEQ ID NO:
• 46;
• (ii) a LCDR2 having the amino acid sequence of SEQ ID NO:
• 48;
• and
• (iii) a LCDR3 having the amino acid sequence of SEQ ID NO:
• 50,
• wherein the anti-Candida antibody molecule binds to the Candida cell or a hyphae of the cell,
• and wherein the method further comprises detecting the bound anti-Candida antibody to identify or detect the Candida cell or a hyphae of the Candida cell.