Compositions and methods of inhibiting the binding of plasma IgG autoantibodies to serotonin 2A receptor
AssigneeThe United States Government as represented by the Department of Veterans Affairs
InventorMark B. Zimering
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Abstract
Disclosed herein, are decoy peptides or polypeptides capable of inhibiting binding of 5-HT2A autoantibodies to a second extracellular loop region of the 5-HT2A receptor, and a pharmaceutical composition containing the decoy peptides or polypeptides and methods of use.
Claims20
A decoy peptide consisting of the sequence of QDDSKVFKEGSCLLADDN (SEQ ID NO:
- 1), or a fragment thereof, wherein the fragment of SEQ ID NO:
- 1 consists of 4 to 9 amino acids in length, and wherein the decoy peptide inhibits the binding of 5-HT2A receptor autoantibodies to a second extracellular loop region of the 5-HT2A receptor.
A method of treating a subject with a disease or disorder, the method comprising:
- administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a decoy peptide comprising the sequence of SEQ ID NO:
- 2 and a pharmaceutically acceptable carrier, wherein the disease or disorder is a metabolic disease or disorder, a cardiovascular or a microvascular disease or disorder, or a neurodegenerative disease or disorder.
A method of treating a subject with a neurologic disease or disorder, the method comprising:
- administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a decoy peptide comprising the sequence of SEQ ID NO:
- 2 and a pharmaceutically acceptable carrier, wherein the neurologic disease or disorder is neuropathy, dementia, major depressive disorder or Parkinson's disease.
A method of inducing sedation in a subject, the method comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a decoy peptide comprising SEQ ID NO:
- 2, and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.