1,3-di-substituted ketene compound and application thereof

A 1,3-disubstituted ketene compound having a structure represented by formula (I) or a pharmaceutically acceptable salt thereof or a stereoisomer thereof or a prodrug molecule thereof:

• wherein R1 and R2 are each independently selected from the group consisting of H, halogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C3-C8 cycloalkylmethyl, C1-C6 alkoxy, and hydroxyl;
• R3 and R4 are each independently selected from the group consisting of H, halogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C3-C8 cycloalkylmethyl, C1-C6 alkoxy, and hydroxyl, and R3 and R4 are not H at the same time;
• or R3 and R4 are bonded to form a 3-8 membered carbocyclic ring or a 3-8 membered heterocyclic ring;
• R5 is selected from the group consisting of OR6 and NR7R8;
• Q is a single bond or CR7R8;
• R6, R7, and R8 are each independently selected from the group consisting of H, C1-C6 alkyl, C3-C8 cycloalkyl, and C3-C8 cycloalkylmethyl;
• W, W1, and Y are each independently selected from the group consisting of O and S;
• ring A is selected from the group consisting of the following structures,
• where X1, X2, X3, X4, X5, X6, and X7 are each independently selected from the group consisting of CR9, CR12, and N, and at least one of X1, X2, X3, and X4 is CR12;
• R9 is selected from the group consisting of H, halogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C3-C8 cycloalkylmethyl, halogen-substituted C1-C6 alkyl, hydroxy-substituted C1-C6 alkyl, alkoxy-substituted C1-C6 alkyl, amino-substituted C1-C6 alkyl, C1-C4 alkylamino-substituted C1-C6 alkyl, aryl, heteroaryl, nitro, cyano, —OR, —N(R)2, —SR, —C(O)OR, —C(O)N(R)2, —C(O)R, —S(O)R, —S(O)2R, —S(O)2N(R)2, and —N(R)C(O)R;
• R10 is selected from the group consisting of H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C3-C8 cycloalkylmethyl, halogen-substituted C1-C6 alkyl, hydroxy-substituted C1-C6 alkyl, alkoxy-substituted C1-C6 alkyl, amino-substituted C1-C6 alkyl, and C1-C4 alkylamino-substituted C1-C6 alkyl;
• R11 is selected from the group consisting of H, —SR, —OR, —N(R)2, C1-C6 alkyl, C3-C8 cycloalkyl, and C3-C8 cycloalkylmethyl;
• R12 is selected from the group consisting of H, —SR, —OR, —N(R)2, C1-C6 alkyl, C3-C8 cycloalkyl, and C3-C8 cycloalkylmethyl;
• n is 0, 1, or 2;
• and
• each of R is selected from the group consisting of H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C3-C8 cycloalkylmethyl, halogen-substituted C1-C6 alkyl, hydroxy-substituted C1-C6 alkyl, alkoxy-substituted C1-C6 alkyl, amino-substituted C1-C6 alkyl, and C1-C4 alkylamino-substituted C1-C6 alkyl.