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US 11,306,091 B2Granted
Process for producing fluorinated compounds using alcohol solvent having unsaturated hydrocarbon
AssigneeFuturechem Co., Ltd.
InventorsDae Yoon Chi, Byoung Se Lee, So Young Chu, Hyeon Jin Jeong, Hyeon Seok Kim
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Abstract
The present invention relates to a process for producing an organofluoro compound including [18F]fluorine, and by using a solvent represented by Formula 1 in nucleophilic fluorination reaction, an organofluoro compound may be prepared at a high yield. In addition, since the solvent has very excellent solubility for a precursor compound, the solvent is suitable for the automated synthesis of 18F-labeled radiopharmaceuticals.
Claims8
A process for producing an organofluoro compound, the process comprising:
- reacting an organic compound having a leaving group (LG) with a fluoride in a solvent according to below Reaction 3 in a suitable condition,
- wherein the organic compound having a leaving group is
- the organofluoro compound is
- and X− is an ion generated from the leaving group, wherein R6 and R7 form carbocycle with N, and n is an integer of 0 to 6, wherein the solvent has the following Formula 1:
- in Formula 1, R1and R2 are each a methyl group;
- and R3 is ethenyl or ethynyl, and wherein the fluoride is a [18F] fluoride, and is provided as a component of a phase transfer catalyst.
3 more elements
Dependencies are inferred from the claim text.