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US 11,306,089 B2Granted
Gamma-carboline compounds for the detection of Tau aggregates
AssigneeLife Molecular Imaging SA
InventorsMathias Berndt, Andre Müller, Felix Oden, Hanno Schieferstein, Heribert Schmitt-Willich, Heiko Kroth, Jérôme Molette
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Abstract
The present invention relates to novel compounds of the formula (II) and formula (III) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.
Claims31
A compound of the formula (II)
- as well as pharmaceutically acceptable salts, hydrates, solvates, prodrugs and polymorphs thereof;
- wherein R1 is selected from the group consisting of 18F, F and LG;
- R2 is H or PG;
- PG is a protecting group;
- LG is a leaving group,
- wherein the hydrogen in formula II are independently selected from 1H, 2H and 3H.
3 more elements
A compound of the formula (III)
- as well as pharmaceutically acceptable salts, hydrates, solvates, prodrugs and polymorphs thereof;
- wherein
- R1 is selected from the group consisting of 18F, F and LG;
- R2 is H or PG;
- PG is a protecting group;
- LG is a leaving group,
- wherein the hydrogen in the formula III are independently selected from 1H, 2H and 3H.
4 more elements
Dependencies are inferred from the claim text.