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US 11,306,083 B2Granted
Amide substituted imidazo[4,5-C]quinoline compounds with a branched chain linking group for use as an immune response modifier
Assignee3M Innovative Properties Company
InventorGeorge W. Griesgraber
Life of this patent
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Abstract
Imidazo[4,5-c]quinoline compounds having an alkylamide substituent that is attached at the N-1 position by a branched chain linking group, single enantiomers of the compounds, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing cytokine biosynthesis in humans and animals, and in the treatment of diseases including infectious and neoplastic diseases are also disclosed. Formula (I):
Claims15
A compound of the Formula (I):
- wherein:
- n is an integer of 0 or 1;
- R is selected from the group consisting of halogen, hydroxy, alkyl, alkoxy, and —C(O)—O-alkyl;
- X is alkylene, wherein the alkylene group can be optionally interrupted by one or more —O— groups;
- R1 is selected from the group consisting of C1-5alkyl and —C1-3alkylene-O—C1-3alkyl;
- R2 is selected from the group consisting of hydrogen, methyl, ethyl, n-propyl, n-butyl, —CH2OCH3, —CH2OCH2CH3, and —CH2CH2OCH3;
- R3 is alkyl, wherein the alkyl group can be optionally interrupted by one or more —O— groups;
- R4 is selected from the group consisting of hydrogen, methyl, ethyl, n-propyl, and isopropyl;
- or a pharmaceutically acceptable salt thereof.
6 more elements
Dependencies are inferred from the claim text.