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US 11,306,082 B2Granted
Esters of dihydrotetrabenazine
AssigneeForesee Pharmaceuticals Co., Ltd.
InventorsYuhua Li, Chen-Chang Lee, Wen-Yen Huang
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Abstract
The present invention relates to a compound of formula (I) including any stereochemically isomeric form thereof, or a pharmaceutically acceptable salt thereof. wherein R1 is —C(═O)O-alkyl, carbonate ester, or —C(═O)-alkyl, ester, or —C(═O)N-alkyl, carbamate ester and wherein R2 is —CH3 or —CD3. The alkyl ester can contain saturated or unsaturated C12 to C26 alkyl carbon. The alkyl carbon chain can have either a straight, branched, noncyclic, cyclic, unsubstituted or substituted structure.
Claims14
A compound of formula (I)
- or a pharmaceutically acceptable salt thereof;
- wherein R1 is selected from the group consisting of —C(═O)O-alkyl, —C(═O)-alkyl, and —C(═O)N-alkyl, and wherein the alkyl is a saturated or unsaturated straight-chain alkyl group containing from 11 to 25 carbon atoms, and R2 is —CH3 or —CD3.
A compound of a formula of (Ib)
- or a pharmaceutically acceptable salt thereof;
- wherein R is a saturated or unsaturated straight-chain alkyl group containing from 11 to 25 carbon atoms.
Dependencies are inferred from the claim text.