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US 11,306,071 B2Granted
Heterocyclic compounds as adenosine antagonists
AssigneeNuvation Bio Inc.
InventorsSon Minh Pham, Jayakanth Kankanala, Pradeep S. Jadhavar, Baban Mohan Mulik, Farha Khan, Sreekanth A. Ramachandran
Life of this patent
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Abstract
5,6-disubstituted 2-aminopyrazine compounds as modulators of an adenosine receptor are provided. The compounds may find use as therapeutic agents for the treatment of diseases mediated through a G-protein-coupled receptor signaling pathway and may find particular use in oncology.
Claims20
A compound of the formula (III):
- or a tautomer or stereoisomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein:
- A is
- and
- B is a phenyl substituted with 1 to 3 groups which may be the same or different, wherein at least one group is —CN, and wherein each group is halogen, —CF3, —OH, —OCH3, —CN, —C(O)OCH3, —C(O)OC2H5, —NH2, —NHCH3 or C1-C6 alkyl optionally substituted by halogen, —OH or oxo.
1 more element
Dependencies are inferred from the claim text.