Crystalline forms of plasma kallikrein inhibitors
AssigneesRezolute, Inc., Activesite Pharmaceuticals, Inc.
InventorsSukanto Sinha, Tamie Chilcote, Julian Scott Northen, Jamie Marshall
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Abstract
Pure crystalline forms of 1-benzyl-N-(4-carbamimidoylbenzyl)-1H-pyrazole-4-carboxamide acetate, and an amorphous form, pharmaceutical compositions thereof, and methods for making the same, are disclosed.
Claims6
Crystalline Form I of anhydrous 1-benzyl-N-(4-carbamimidoylbenzyl)-1H-pyrazole-4-carboxamide acetate characterized by an X-ray powder diffraction (XRPD) pattern that comprises peaks at 10.0, 18.1, 18.6, 20.1, and 23.9 degrees, ±0.5 degrees, 2θ, wherein said XRPD is made using Cu Kα radiation, and Crystalline Form I is substantially free of other polymorphic forms of 1-benzyl-N-(4-carbamimidoylbenzyl)-1H-pyrazole-4-carboxamide acetate.
Dependencies are inferred from the claim text.