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US 11,305,274 B2Granted
Disposable bioassay cartridge and method of performing multiple assay steps and fluid transfer within the cartridge
AssigneeAngle Europe Limited
InventorsAlexandre Izmailov, David Englert, Paul Smith
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Abstract
The present disclosure provides a cartridge and method to move fluids within the cartridge that simplifies the design and removes the need for any internal valves or metering devices. The design is amenable to injection molded manufacturing lowering cost for large volume manufacturing. The design can be adapted to carry out both sample preparation and detection of biological substances including nucleic acids and proteins.
Claims20
A system for detection of analytes present in liquid samples, comprising:
- a light detector;
- and
- a generally planar microporous substrate material having opposed surfaces and tapered micropores extending completely through a thickness of said microporous substrate, and wherein ends of the tapered micropores have larger micropore openings on one surface of the microporous substrate compared to smaller pore openings on the opposed surface;
- analyte-specific receptors to the analytes bound inside the micropores to walls of the tapered micropores having the wider pore openings, said analyte-specific receptors emit light when analytes in the liquid sample bind to the analyte specific sensors;
- and
- said microporous substrate being spaced from said light detector with said light detector facing the surface of said microporous substrate having the larger micropore openings to provide an increase in collection efficiency of light emitted from analyte-specific receptors in said micropores detected by said light detector compared to a light collection efficiency of light emitted from the analyte-specific receptors when the micropores are straight and not tapered.
3 more elements
Dependencies are inferred from the claim text.