System and method for pacing parameter optimization using heart sounds

A medical device system comprising:

• therapy delivery circuitry;
• an acoustical sensor;
• and
• processing circuitry, coupled to an external display, the processing circuitry configured to:
• control delivery of pacing pulses by the therapy delivery circuitry at varying pacing settings, obtain heart sound signals from the acoustical sensor, determine, based on the heart sound signals, a plurality of heart sound signal parameters, determine, based on the heart sound signal parameters, a relative change of a V-S2 interval, wherein the V-S2 interval is a time interval between a ventricular electrical event and an S2 heart sound, and wherein the relative change of the V-S2 interval is responsive to the varying pacing settings, identify, based on the relative change of the V-S2 interval, a target pacing parameter, control delivery of pacing pulses at the target pacing parameter, and derive a trend of the V-S2 interval with respect to the varying pacing settings, wherein the external display configured to present a trend of the V-S2 interval with respect to pacing settings.

A method comprising:

• delivering, by a medical device system, pacing pulses at varying pacing settings;
• obtaining, by the medical device system, electrical signals indicative of ventricular events and heart sound signals from an acoustical sensor;
• determining, by the medical device system based on the electrical signals and the heart sound signals, a relative change of V-S2 intervals, wherein the V-S2 intervals are time intervals between the ventricular events and subsequent S2 heart sounds, and wherein the relative change of the V-S2 intervals is responsive to the varying pacing settings;
• identifying, by the medical device system and based on the relative change of the V-S2 intervals, a target pacing parameter;
• delivering, by the medical device system, pacing pulses according to the target pacing parameter;
• deriving, by the medical device system, a trend of the V-S2 intervals with respect to the varying pacing settings;
• and
• displaying, by the medical device system, the derived trend.

A method comprising:

• delivering, by a medical device system, pacing pulses at varying pacing settings;
• obtaining, by the medical device system, electrical signals indicative of ventricular events and heart sound signals from an acoustical sensor;
• determining, by the medical device system based on the heart sound signals, a plurality of heart sound signal parameters;
• determining, by the medical device system based on the electrical signals and the heart sound signals, a relative change of V-S2 intervals, wherein the V-S2 intervals are time intervals between the ventricular electrical events and subsequent S2 heart sounds, and wherein the relative change of the V-S2 intervals is responsive to the varying pacing settings;
• identifying, by the medical device system and based on the relative change of the V-S2 intervals, a target pacing parameter;
• delivering, by the medical device system, pacing pulses according to the target pacing parameter;
• deriving, by the medical device system, a trend of at least one of the heart sound signal parameters with respect to the varying pacing settings;
• and
• displaying, by the medical device system, the derived trend.