Mixing vial

A syringe system, the system comprising:

• a syringe with an axially movable plunger having a distal end defining a shoulder, wherein a harpoon extends axially from the distal end of the plunger, wherein the shoulder has a larger diameter than a harpoon minimum diameter, wherein the harpoon is static with respect to the plunger;
• and
• a mixing vial for use in the syringe, said mixing vial including:
• a vessel, the vessel comprising a hollow interior chamber with proximal and distal ends, a neck at the proximal end, the neck having distal and proximal open ends;
• and
• a stopper-pistol the stopper-piston comprising a hollow interior chamber with an open distal end and a closed proximal end, and the entire shipper-piston being slidably positioned in a sealing relationship with said neck, wherein the entire stopper-piston is slidable from a first position to a second position, wherein the entire stopper-piston is adjacent the proximal end of the vessel when in the first position, and wherein the entire stopper-piston is closer to the distal end of the vessel than to the proximal end of the vessel when in the second position;
• and
• a dislodgeable plug positioned in and sealing said open distal end of said hollow interior chamber of the stopper-piston, wherein the entire dislodgeable plug is fully dislodgeable as a single piece from the open distal end of the stopper-piston;
• wherein said stopper-piston comprises a radially inwardly extending flange, wherein the radially inwardly extending flange defines an inward facing annular groove that receives an edge of the dislodgeable plug,
• wherein a stopper-piston breakout force is required to cause the stopper-piston to slide in a direction from the first position toward the second position, and a plug dislodging force is required to fully dislodge the dislodgeable plug from the inward facing annular groove defined by the radially inwardly extending flange of the stopper-piston in the direction from the first position toward the second position, wherein the plug dislodging force is less than the stopper-piston breakout force;
• and
• wherein, when the mixing vial is disposed in the syringe and the plunger is axially moved, the harpoon penetrates the closed proximal end of the stopper-piston, contacts the dislodgeable plug, and fully dislodges the dislodgeable plug prior to the shoulder of the plunger contacting the closed proximal end of the stopper-piston.