Back to results
US 11,305,045 B2Granted
Blood processing apparatus and method for detoxifying bacterial lipopolysaccharide
AssigneeOrth Consulting, LLC
InventorDonald S. Orth
Life of this patent
Estimating the term…
Abstract
A detoxification method includes the steps of inducing flow of patient blood through an extracorporeal device inlet and outlet in fluid connection to the circulatory system of a patient. Biological agents including lipopolysaccharide (LPS) contained within patient blood can be detoxified by passing patient blood over a biochemical reactor surface having attached or immobilized Saccharomyces boulardii alkaline phosphatase enzyme, with the biochemical reactor being contained within the extracorporeal device. An acyloxyacyl hydrolase enzyme may also be used on the biochemical reactor surface.
Claims11
A detoxification method, comprising:
- inducing flow of blood of a patient through an extracorporeal device inlet and outlet;
- and
- detoxifying at least one biological agent contained within the blood by passing the blood over at least one biochemical reactor surface having attached phosphatase enzyme and acyloxyacyl hydrolase enzyme, with the at least one biochemical reactor surface being contained within the extracorporeal device and wherein the at least one biological agent is selected from the group consisting of:
- Gram negative bacterial lipopolysaccharide (LPS);
- Gram negative bacterial flagellin;
- Gram positive bacterial extracellular lipoteichoic acid;
- Gram positive bacterial flagellin;
- one or more bacterial extracellular nucleotides selected from adenosine triphosphate (ATP), adenosine diphosphate (ADP), deoxyribonucleic acid (DNA), and ribonucleic acid (RNA),
- one or more yeast extracellular nucleotides selected from ATP, ADP, DNA and RNA,
- one or more fungal extracellular nucleotides selected from ATP, ADP, DNA and RNA,
- one or more viral extracellular nucleotides selected from DNA and RNA, and
- one or more host extracellular nucleotides selected from ATP, ADP, DNA, and RNA, and combinations thereof.
9 more elements
Dependencies are inferred from the claim text.