Bioprosthetic tissue having a reduced propensity for in vivo calcification
AssigneeEdwards Lifesciences Corporation
InventorsJames A. Davidson, Jeffrey S. Dove, Darin P. Dobler
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Abstract
A bioprosthetic tissue having a reduced propensity to calcify in vivo, the bioprosthetic tissue. The bioprosthetic tissue comprises an aldehyde cross-linked and stressed bioprosthetic tissue comprising exposed calcium, phosphate or immunogenic binding sites that have been reacted with a calcification mitigant. The bioprosthetic tissue has a reduced propensity to calcify in vivo as compared to aldehyde cross-linked bioprosthetic tissue that has not been stressed and reacted with the calcification mitigant.
Claims20
A method of treating a cross-linked bioprosthetic tissue to reduce in vivo calcification, the method comprising:
- immersing a cross-linked bioprosthetic tissue in a solution comprising a calcification mitigant;
- and
- stressing the cross-linked bioprosthetic tissue by subjecting the cross-linked bioprosthetic tissue to pulsed fluid flow in the solution comprising the calcification mitigant;
- wherein the stressing produces localized micro collagen fibril damage at sites of flexion and acid binding sites;
- and
- wherein the calcification mitigant couples with the acid binding sites to produce capped acid binding sites.
Dependencies are inferred from the claim text.