Systems and approaches for sterilizing a drug delivery device

An irradiation shielding member for use in sterilizing a portion of each of the plurality of drug container assemblies by irradiation, the irradiation shielding member comprising:

• a housing comprising a first shielding portion and a second shielding portion,
• the first shielding portion including a first surface, a second surface opposite the first surface, and a plurality of first bore portions extending between the first and second surfaces,
• the second shielding portion having a first surface and a second surface opposite the first surface, the first surface of the second shielding portion coupled to the second surface of the first shielding portion, and a plurality of second bore portions corresponding to and aligned with the plurality of first bore portions,
• wherein the first and second bore portions cooperate to form a plurality of receptacles including a plurality of openings in the first surface of the first shielding portion of the housing,
• the plurality of receptacles sized and configured to receive the plurality of drug container assemblies, each of the plurality of drug container assemblies comprising a container with a drug contacting surface, a drug contact region, and a seal member disposed adjacent the container contact region to seal the contents of the container at a sealing interface, such that each of the plurality of drug container assemblies is exposed out of the housing through the openings and the container contact region and at least a portion of the seal member are disposed within the first bore portions,
• wherein the irradiation shielding member is configured to permit sterilization by an irradiation exposure of the sealing interface of each of the plurality of container assemblies while restricting sterilization by the irradiation exposure to the drug contacting surface of each of the plurality of container assemblies, the irradiation exposure is non-parallel relative to the first surface of the first shielding portion;
• wherein the first shielding portion is a single component;
• and
• wherein each of the plurality of first bore portions has a first diameter, and each of the plurality of second bore portions has a second diameter that is greater than the first diameter.