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US 11,305,024 B2Granted
Cross-linked polymer modified nanoparticles
AssigneesOregon Health & Science University, PDX Pharmaceuticals, Inc.
InventorsWassana Yantasee, Worapol Ngamcherdtrakul, Jingga Morry, David Castro, Joe William Gray
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Abstract
Disclosed herein are nanoconstructs comprising a nanoparticle, coated with additional agents such as cationic polymers, stabilizers, targeting molecules, labels, oligonucleotides and small molecules. These constructs may be used to deliver compounds to treat solid tumors and to diagnose cancer and other diseases. Further disclosed are methods of making such compounds and use of such compounds to treat or diagnose human disease.
Claims30
A composition comprising:
- a plurality of multilayer nanoconstructs each comprising:
- about 10% to about 30% by weight cross-linked polyethylenimine (PEI) bound to an exterior surface of a silica nanoparticle, a silicon nanoparticle, an iron oxide nanoparticle, a silver nanoparticle, or a carbon nanotube;
- and
- polyethylene glycol (PEG) bound to the PEI or to the nanoparticle;
- wherein the nanoconstructs have a hydrodynamic size Z-average diameter of about 200 nm or less;
- and the plurality of nanoconstructs have a polydispersity index (PDI) of no more than about 0.37;
- and
- an oligonucleotide non-covalently attached to the PEI.
5 more elements
Dependencies are inferred from the claim text.