Methods for distributing high levels of therapeutic agent throughout the cortex to treat neurological disorders
AssigneeThe Regents of the University of California
InventorsKrystof Bankiewicz, Adrian P. Kells
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Abstract
The invention provides methods for treating neurological disorders, which involve administering therapeutic agents to the thalamus by convection enhanced delivery.
Claims13
A method for delivering an Adeno Associated Virus (AAV) therapeutic agent to neurons of the cerebral cortex in a primate by anterograde transport from the thalamus, comprising administering said AAV therapeutic agent into the thalamus of said primate by convection enhanced delivery (CED) at an infusion rate greater than 0.5 μl/min, thereby delivering the AAV therapeutic agent to neurons of multiple cortical layers of the primate cerebral cortex.
Dependencies are inferred from the claim text.