Linear polyester and semi-linear glycidol polymer systems: formulation and synthesis of novel monomers and macromolecular structures
AssigneeVanderbilt University
InventorsEva M. Harth, Dain B. Beezer, GuangZhao Li, Benjamin R. Spears, David M. Stevens
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Abstract
Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for drug delivery. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Claims11
A method for making a polymer, the method comprising polymerizing glycidol to form the polymer, the polymer comprising repeating units selected from:
- wherein R0 is selected from H, alkyl, NH2, and R1;
- wherein R1 comprises a crosslinking functionality;
- and
- wherein the ratio of (A1+A2):(B1+B2) is greater than 5.
A method for making a polymer, the method comprising polymerizing glycidol to form the polymer, the polymer comprising at least one repeating unit formed from a monomer selected from:
- or a combination thereof.
A method of forming a nanoparticle comprising:
- polymerizing glycidol to form a polymer, the polymer comprising at least one repeating unit formed from a monomer selected from:
- or a combination thereof;
- and
- crosslinking the polymer with crosslinks, wherein the crosslinks comprise:
- wherein at least one of
- is not 0, thereby forming the nanoparticle.
Dependencies are inferred from the claim text.