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US 11,305,014 B2Granted
Modulating permeability of the blood cerebrospinal fluid barrier
AssigneeMemorial Sloan Kettering Cancer Center
InventorsAdrienne Boire, Joan Massague
Life of this patent
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Abstract
The present invention relates to methods and compositions for modulating the blood CSF barrier and for diagnosing, preventing and/or treating leptomeningeal metastasis. In particular embodiments of the invention, the permeability of the blood CSF barrier is modulated by agonists or antagonists of Complement Component 3 (C3) or its receptor.
Claims12
A method of treating leptomeningeal metastasis in a subject with cancer, comprising diagnosing leptomeningeal metastasis in the subject and administering an effective inhibitory amount of an antagonist of C3 or C3aR to the subject.
Dependencies are inferred from the claim text.