Recombinant virus with diminished latency and methods of using same
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsJeffrey I. Cohen, Lesley Pesnicak
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Abstract
The disclosure provides recombinant herpes virus with diminished latency. In embodiments, the recombinant herpes virus comprises a latency gene or transcript linked to an altered or heterologous promoter. The disclosure also provides compositions and methods for inducing immunity in animals using the recombinant herpes viruses.
Claims7
A method of inhibiting latent viral infection, comprising administering to a subject a recombinant virus comprising all or a portion of a herpes virus genome, wherein the genome has a promoter for a latency gene or transcript altered or modified, and the gene or transcript is expressed from the virus genome during virus replication.
Dependencies are inferred from the claim text.