Zika virus chimeric polyepitope comprising non-structural proteins and its use in an immunogenic composition

A chimeric polyepitope comprising (i) at least the following T-cell epitopes of (a) and (b), or (ii) at least the following T-cell epitopes of (a) and (c), or (iii) at least the following T-cell epitopes of (b) and (c):

• (a) a T-cell epitope of the non-structural (NS) NS1 protein of a Zika virus (ZIKV) comprising or consisting of an amino acid sequence selected from the group consisting of SEQ ID NOs:
• 10-12, 14, 15, 17-19, 23, 24 and 78-83,
• (b) a T-cell epitope of the NS3 protein of a ZIKV comprising or consisting of an amino acid sequence selected from the group consisting of SEQ ID NOs:
• 28, 29, 31, 33-35, 84 and 85,
• (c) a T-cell epitope of the NS5 protein of a ZIKV comprising or consisting of an amino acid sequence selected from the group consisting of SEQ ID NOs:
• 46, 48-50, 52-55, 57-60, 62, 64, 67, 69, 72, 73 and 86-91,
• or a T-cell epitope variant thereof, which differs from the original amino acid sequence of the T-cell epitope of (a), (b) or (c) by point mutation of one or more amino acid residues and which has at least 90% sequence identity or more than 95% sequence identity or 99% sequence identity with said original sequence.